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Series GSE69945 Query DataSets for GSE69945
Status Public on Jun 18, 2015
Title Mouse lung tissue transcriptome response to H1N1, H5N1, and mutants [mRNA]
Organism Mus musculus
Experiment type Expression profiling by array
Summary The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in mouse lung infected with WT A/Vietnam/1203/2004 (H5N1; 'VN1203'), VN1203-NS1trunc124, and WT A/California/04/2009 (H1N1; 'CA04').
Overall design Groups of 22-week-old C57BL/6 mice were infected with WT A/Vietnam/1203/2004 (H5N1; 'VN1203'), VN12013-PB2-627E, VN1203-NS1trunc124, and WT A/California/04/2009 (H1N1; 'CA04').Infections were done at 176 PFU/mouse for VN1203, 1100 PFU/mouse for VN1203-NS1trunc124, and 10^4 PFU/mouse for CA04. Time points were 1, 2, 4, and 7 d.p.i. There were 5 mice for all infection groups and 3 mice for all mock groups. Lung samples were collected for virus load, transcriptional and proteomics analysis. Weight loss and animal survival were also monitored.
Contributor(s) Stratton K, Waters KM, Eisfeld AJ, Kawaoka Y
Citation(s) 34051754, 38565538
Submission date Jun 17, 2015
Last update date Jun 19, 2024
Contact name Natalie Heller
Organization name PNNL
Street address 902 Battelle Blvd.
City Richland
ZIP/Postal code 99354
Country USA
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (67)
GSM1713618 IM101_Mock_1d_RNA_1
GSM1713619 IM101_Mock_1d_RNA_2
GSM1713620 IM101_Mock_1d_RNA_3
This SubSeries is part of SuperSeries:
GSE65575 Modeling Host Responses to Understand Severe Human Virus Infections
BioProject PRJNA287214

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE69945_RAW.tar 144.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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