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Series GSE6932 Query DataSets for GSE6932
Status Public on Feb 07, 2007
Title Identification and characterization of small molecule inducers of epidermal keratinocyte differentiation
Organism Homo sapiens
Experiment type Expression profiling by array
Summary An essential function of the human epidermis is the maintenance of a protective barrier against the environment. As a consequence, keratinocytes, which make up this layer of the skin, undergo an elaborate process of self-renewal, terminal differentiation and cell death. Misregulation of these processes can lead to several human diseases including psoriasis and basal cell and squamous cell carcinomas. To identify novel regulators of keratinocyte differentiation, a cell-based screen of small molecule libraries was carried out for molecules that induce terminal differentiation of normal human epidermal keratinocytes (NHEKs). One class of molecules was identified, the 2-(3,4,5-trimethoxy-phenylamino)-pyrrolo[2,3-d]pyrimidines, which were shown to induce differentiation of epidermal progenitor cells to terminally differentiated keratinocytes. These molecules serve as useful mechanistic probes of the cellular differentiation programs that regulate the formation and homeostasis of the epidermis, and may lead to novel therapeutic approaches for the treatment of skin hyperproliferative disorders.
Keywords: time course of compound treatment
Overall design samples were taken from duplicate treatments of cells with DMSO or PP-2 (compound 9) at various time points
Contributor(s) Hong J, Lee J, Min KH, Walker JR, Gray NS, Cho CY, Schultz PG, Peters EC
Citation(s) 17348628
Submission date Feb 01, 2007
Last update date Aug 10, 2018
Contact name John R Walker
Phone 858-812-1636
Organization name Genomics Institute of the Novartis Research Foundation
Lab Genetics Core
Street address 10675 John Jay Hopkins
City San Diego
State/province CA
ZIP/Postal code 92121
Country USA
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (18)
GSM159933 DMSO O hr 1
GSM159934 DMSO O hr 2
GSM159935 DMSO 12 hr 1
BioProject PRJNA98097

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Supplementary file Size Download File type/resource
GSE6932_RAW.tar 64.4 Mb (http)(custom) TAR (of CEL)

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