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Series GSE69151 Query DataSets for GSE69151
Status Public on May 31, 2016
Title TNFalpha and IL-6 induced anorexia: effects on serotonin turnover
Organism Mus musculus
Experiment type Expression profiling by array
Summary Anorexia can occur as a serious complication of chronic disease. Increasing evidence suggests that inflammation plays a major role, along with a hypothalamic dysregulation characterized by locally elevated serotonin levels. The present study was undertaken to further explore the connections between peripheral inflammation, anorexia and hypothalamic serotonin metabolism and signaling pathways. We studied transcriptomic changes and serotonergic activity in the hypothalamus of mice after an intraperitoneal injection with TNFα, IL-6 or a combination of TNFα and IL-6.
Overall design C57BL/6 mice were intraperitoneally injected with TNFalpha, IL-6 Low, IL-6 High, combination TNF+IL-6 Low or combination TNF+IL-6 High. Each group comprised of 12 animals, of which 6 animals were used for transcriptomics.
Contributor(s) Dwarkasing J, Witkamp R, Boekschoten MV, ter Laak M, Flik G, van Norren K
Citation(s) 27207102
Submission date May 21, 2015
Last update date Apr 18, 2017
Contact name Guido Hooiveld
Organization name Wageningen University
Department Div. Human Nutrition & Health
Lab Nutrition, Metabolism & Genomics Group
Street address HELIX, Stippeneng 4
City Wageningen
ZIP/Postal code NL-6708WE
Country Netherlands
Platforms (1)
GPL11533 [MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]
Samples (36)
GSM1693960 hypothalamus, control, replicate 1
GSM1693961 hypothalamus, TNFa low, replicate 1
GSM1693962 hypothalamus, IL6 low, replicate 1
BioProject PRJNA284645

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE69151_RAW.tar 161.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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