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Series GSE69083 Query DataSets for GSE69083
Status Public on Jul 01, 2016
Title Replication timing of control and siRNA PR-set7 cells
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the monomethylation, is a critical determinant of licensing and time activation of replication origins in mammalian cells.
Overall design Two experimental condition : shRNA LUC cells (control) versus siRNA Prset-7 cells
Contributor(s) Brustel J, Dulev S, Kirstein N, Izard F, Grimaud C, Cayrou C, Schotta G, Mechali M, Baldacci G, Sardet C, Batada NN, Cadoret J, Schepers A, Julien E
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Submission date May 20, 2015
Last update date Jul 02, 2016
Contact name Jean-Charles Cadoret
Organization name CNRS/ Université de Paris
Street address 15 rue hélène Brion
City Paris
ZIP/Postal code 75013
Country France
Platforms (1)
GPL10123 Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version)
Samples (2)
GSM1692635 siRNA luc replication timing 1
GSM1692636 siRNA prset-7 replication timing 1
This SubSeries is part of SuperSeries:
GSE69085 Degree of H4-K20me defines distinct subsets of replication origins in active and silent chromatin domains of mammalian cells
BioProject PRJNA284499

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE69083_RAW.tar 105.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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