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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 20, 2015 |
| Title |
Genetic ablation of CD38 protects against Western diet-induced exercise intolerance and metabolic inflexibility |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
CD38, a multi-functional membrane receptor and enzyme, consumes NAD+ to generate products such as cyclic-ADP-ribose. CD38 knockout mice show elevated tissue and blood NAD+ level. Chronic feeding of high-fat, high-sucrose diet to wild type mice leads to exercise intolerance and reduced metabolic flexibility. Loss of CD38 by genetic mutation protects mice from diet-induced metabolic deficit. These animal model results suggest that elevation of tissue NAD+ through genetic ablation of CD38 can profoundly alter energy homeostasis in animals that are maintained on a calorically-excessive Western diet.
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| Overall design |
Mouse gastrocnemius muscle samples were used in a factor design, where genotype could be WT or KO, and exercise could be sedentary or treadmill. 4 biological replicates were included in each group.
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| Contributor(s) |
Chiang S, Harrington WW, Luo G, Milliken NO, Ulrich JC, Chen J, Rajpal DK, Qian Y, Carpenter T, Murray R, Geske RS, Stimpson SA, Kramer HF, Haffner CD, Becherer JD, Preugschat F, Billin AN |
| Citation(s) |
26287487 |
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| Submission date |
May 19, 2015 |
| Last update date |
Aug 20, 2015 |
| Contact name |
Jing Chen |
| Organization name |
CCHMC
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| Street address |
3333 Burnet Ave
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| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
| GPL19559 |
[Mouse4302_Mm_EntrezG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Mouse4302_Mm_ENTREZG_18.0.0] |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA284416 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE69062_RAW.tar |
72.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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