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Series GSE68681 Query DataSets for GSE68681
Status Public on Dec 08, 2016
Title Cell density, Her2 and progesterone signaling regulate dissemination of breast cancer cells [Gene expression]
Organism Mus musculus
Experiment type Expression profiling by array
Summary Disseminated breast cancer cells display genotypes disparate from the predominant clone of the primary tumor before manifestation of metastasis, suggesting that cancer cell dissemination occurs preferentially early; however, the underlying molecular mechanisms are unknown. Investigating metastasis in a Her2-driven mouse model, we found that the progesterone-induced paracrine cytokines Wnt4 and Rankl induced migration and early dissemination shortly after Her2 activation. Once tumorigenic growth was established, progesterone receptor (PgR) expression was lost and Wnt4/Rankl induced proliferation. The altered response from migration to proliferation was determined by cell density involving miRNA-regulated PgR expression and was reversible. Cells from early, low-density lesions displayed more functional stemness traits than cells from dense, advanced tumors, migrated more and founded significantly more metastases. The data suggest that many metastases are derived from early-disseminated cancer cells, implying that our concepts for systemic therapy need to be revised.
 
Overall design Gene expression analysis was performed for 10 normal, 7 ADH, 19 primary tumor and 7 lung metastatic tissue samples.
 
Contributor(s) Hosseini H, Hoffmann M, Meister G, Klein CA
Citation(s) 27974799
Submission date May 08, 2015
Last update date Mar 09, 2017
Contact name Christoph Andreas Klein
Organization name University of Regensburg
Department Experimental Medicine and Therapy Research
Street address Franz-Josef-Strauß-Allee 11
City Regensburg
State/province Bavaria
ZIP/Postal code 93053
Country Germany
 
Platforms (1)
GPL13188 Operon OpArray - Mus Musculus - 38k v4.0.3
Samples (43)
GSM1678944 A1
GSM1678945 A2
GSM1678946 A3
This SubSeries is part of SuperSeries:
GSE68683 Cell density, Her2 and progesterone signaling regulate dissemination of breast cancer cells
Relations
BioProject PRJNA283390

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE68681_RAW.tar 111.5 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table

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