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Series GSE68189 Query DataSets for GSE68189
Status Public on Apr 23, 2015
Title Comprehensive analysis of microRNA expression in the human developing brain reveals microRNA-10 as a caudalizing factor
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human brain development remains largely unexplored. Here, we provide a comprehensive analysis of miRNA expression of regionalized neural progenitor cells derived from human embryonic stem cells and human fetal brain. We found that several miRNAs displaying both age-specific and region-specific expression patterns. Among these miRNAs we identified miR-10 to be specifically expressed in the human hindbrain and spinal cord, while absent from rostral regions. Gain-of-function experiments further demonstrated that miR-10 alone could drive caudalization of human neural progenitors cells. Together, these data confirms a role for miRNAs in establishing different human neural progenitor populations. This data set also provides a comprehensive resource for future studies investigating the functional role of different miRNAs in human brain development
Overall design MicroRNA sequencing of 34 samples from human embryonic stem cells and human fetal brains.
Contributor(s) Jönsson ME, Nelander Wahlestedt J, Åkerblom M, Kirkeby A, Jakobsson J, Parmar M
Citation(s) 26395143
Submission date Apr 23, 2015
Last update date May 15, 2019
Contact name Malin Parmar
Organization name Lund University
Department Wallenberg Neuroscience Center
Street address BMC A11
City Lund
ZIP/Postal code 22184
Country Sweden
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (34)
GSM1665365 NS cells (Sample 1)
GSM1665366 NS cells (Sample 2)
GSM1665367 NS cells (Sample 3)
BioProject PRJNA282001
SRA SRP057590

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE68189_normalized_counts.csv.gz 173.5 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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