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| Status |
Public on Apr 20, 2015 |
| Title |
The alteration of DNA methylation driven by HIV infection based on a pair of monozygotic twins (MeDIP-chip) |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
In this study, we have investigated the relationship between genome-wide DNA methylation pattern and HIV infection using the methylated DNA immunoprecipitation - microarray method. A pair of monozygotic twins was recruited: one of the twins was infected with HIV while the other was not.
The immunoprecipitated CpG-methylated DNA from HIV positive subject (test) and from HIV negative subject (input control) were labelled with Cy5 and Cy3 respectively
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| Overall design |
The methylated genomic DNA fragments from HIV+ and HIV- twins were hybridized on the same chip since the identical genetic background
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| Contributor(s) |
Zhang Y, Tsui S |
| Citation(s) |
26039376, 26697319 |
| |
| Submission date |
Apr 20, 2015 |
| Last update date |
Dec 24, 2015 |
| Contact name |
Yinfeng Zhang |
| E-mail(s) |
hkbic.cuhk@gmail.com
|
| Organization name |
The Chinese University of Hong Kong
|
| Street address |
1 shatin road
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| City |
Hong Kong |
| ZIP/Postal code |
0000 |
| Country |
Hong Kong |
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| Platforms (1) |
| GPL16284 |
NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1] |
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| Samples (1) |
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| Relations |
| BioProject |
PRJNA281583 |
