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Series GSE67931 Query DataSets for GSE67931
Status Public on May 05, 2016
Title Disruption of Na+/H+ exchanger regulatory factor 2 scaffold suppresses colon cancer proliferation
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary A key function of Na+/H+ exchanger regulatory factor 2 (NHERF2) is spatial organization of signaling proteins to facilitate signal transduction. The role of NHERF2 in cancer progress is not well understood. This study determines how loss of NHERF2 alter colon cancer progress.
Overall design We show that loss of NHERF2 decreases colon cancer cell proliferation. To compare the effects of NHERF2 and LPA2 at the molecular level, HCT116 colon cancer xenograft with knockdown of NHERF2 or LPA2 was analyzed by RNAseq.

Please note that standard cufflinks/cuffdiff output files are provided in the compressed tar files as processed data and Cufflinks/Cuffdiff output file content/formats are described at:
(also included in the 'readme.txt' file)
Contributor(s) Yun C
Citation(s) 26867566
Submission date Apr 15, 2015
Last update date May 15, 2019
Contact name Viren Patel
Organization name Emory University School of Medicine
Department EICC
Street address 101 Woodruff Circle
City Atlanta
State/province GA
ZIP/Postal code 30322
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (9)
GSM1658681 701R1 - pLKO1
GSM1658682 702R1 - pLK01
GSM1658683 703R1 - pLK01
BioProject PRJNA281231
SRA SRP057199

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE67931_RAW.tar 71.1 Mb (http)(custom) TAR (of TAR)
GSE67931_cuffdiff_out_pLKO1_vs_shLPA2.tar.gz 17.6 Mb (ftp)(http) TAR
GSE67931_cuffdiff_out_pLKO1_vs_shNHERF2.tar.gz 17.6 Mb (ftp)(http) TAR
GSE67931_cuffdiff_out_shLPA2_vs_shNHERF2.tar.gz 17.6 Mb (ftp)(http) TAR
GSE67931_readme.txt 929 b (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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