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| Status |
Public on Jun 05, 2007 |
| Title |
Expression data from wildtype and Rb-/- fetal liver at e12.5 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Rb null embryos exhibit defective fetal liver erythropoiesis. We used microarrays to compare Wt and Rb null fetal livers and to analyse gene expression differences which accompany and may underlie Rb null fetal liver degeneration, erythroid failure, and erythropoietic island dissolution.
We used microarrays to compare Wt and Rb null fetal livers and analyse gene expression changes which accompany and may underlie fetal liver.
Keywords: retinoblastoma, fetal liver, erythroblast, macrophage, cell death
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| Overall design |
Wild type and Rb null embryos were sacrificed at e12.5 and fetal livers were dissected for RNA extraction. Three embryos of each genotype were analysed.
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| Contributor(s) |
Dibling BC, Spike BT, Macleod KF |
| Citation(s) |
17557897 |
| |
| Submission date |
Jan 18, 2007 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Kay F Macleod |
| E-mail(s) |
kmacleod@huggins.bsd.uchicago.edu
|
| Organization name |
Ben May Institute/University of Chicago
|
| Street address |
927 E 57th St
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60637 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (6)
|
| GSM156784 |
Rb null fetal liver 1, embryo at 12.5 days of development |
| GSM156785 |
Rb null fetal liver 2, embryo at 12.5 days of development |
| GSM156786 |
Rb null fetal liver 3, embryo at 12.5 days of development |
| GSM156787 |
Wild type fetal liver 1, embryo at 12.5 days of development |
| GSM156788 |
Wild type fetal liver 2, embryo at 12.5 days of development |
| GSM156789 |
Wild type fetal liver 3, embryo at 12.5 days of development |
|
| Relations |
| BioProject |
PRJNA99231 |
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