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Series GSE6764 Query DataSets for GSE6764
Status Public on Jun 21, 2007
Title Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Gene expression profiles of 75 tissue samples were analyzed representing the stepwise carcinogenic process from pre-neoplastic lesions (cirrhosis and dysplasia) to HCC, including four neoplastic stages (very early HCC to metastatic tumors) from patients with HCV infection. Gene signatures that accurately reflect the pathological progression of disease at each stage were identified and potential molecular markers for early diagnosis uncovered. Pathway analysis revealed dysregulation of the Notch and Toll-like receptor pathways in cirrhosis, followed by deregulation of several components of the Jak/STAT pathway in early carcinogenesis, then up-regulation of genes involved in DNA replication and repair and cell cycle in late cancerous stages.
Keywords: 8 pathological stages of HCV-induced HCC
 
Overall design 75 samples covering 8 stages of HCV induced HCC, with up to 13 biological repeats for each stage. Normal liver were used as control.
 
Contributor(s) Wurmbach E, Chen Y, Khitrov G, Zhang W, Roayaie S, Schwartz M, Fiel I, Thung S, Mazzaferro V, Bruix J, Bottinger E, Friedman S, Waxman S, Llovet JM
Citation(s) 17393520
Submission date Jan 17, 2007
Last update date Mar 25, 2019
Contact name Elisa Wurmbach
E-mail(s) Elisa.Wurmbach@mssm.edu
Phone 212-241-9779
Organization name Mount Sinai School of Medicine
Department Hematology/Oncology
Lab Sam Waxman
Street address 1 Gustave L. Levy Place
City New York
State/province NY
ZIP/Postal code 10029
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (75)
GSM155919 c_NY101
GSM155920 ci_NY3
GSM155921 ci_NY17
Relations
BioProject PRJNA98935

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6764_RAW.tar 588.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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