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Series GSE66874 Query DataSets for GSE66874
Status Public on Jun 06, 2016
Title Expression data of the BMDMs from GPS2 WT and MKO mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Obesity is a major risk factor for metabolic disorders like insulin resistance and diabetes. We previously identified GPS2 as a clinical relavant repressor of metaflammation. No animal KO models were used to study its physiological function in vivo. The role of GPS2 in macrophage activation and inflammation is also largely unknown.
Here we developed a GPS2 myeloid specific KO mice to study the regulation of GPS2 in macrophage inflammation. We found GPS2 ablation was linked with significant upregulation in inflammation markers in BMDMs from this array.
Overall design WT and GPS2 KO BMDMs were differentiated and cultured. Total mRNA was extracted from unstimulated BMDM (n=3 in each group) and hybridized on affymetrix microarrays.
Contributor(s) Fan R, Damdimopoulos A
Citation(s) 27270589
Submission date Mar 13, 2015
Last update date Apr 18, 2017
Contact name Eckardt Treuter
Organization name Karolinska Institute
Department Department of Biosciences and Nutrition
Street address Hälsovägen 7-9
City Huddinge
ZIP/Postal code 141 57
Country Sweden
Platforms (1)
GPL11533 [MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]
Samples (6)
GSM1633670 BMDM_WT_rep1
GSM1633671 BMDM_WT_rep2
GSM1633672 BMDM_WT_rep3
BioProject PRJNA278147

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Supplementary file Size Download File type/resource
GSE66874_RAW.tar 28.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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