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Series GSE66525 Query DataSets for GSE66525
Status Public on Mar 16, 2015
Title A gene expression profile associated with relapse of cytogenetically normal acute myeloid leukemia is enriched for leukemia stem cell genes
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Relapse, associated with therapy resistance, is a major clinical problem in acute myeloid leukemia (AML), yet little is known about the underlying molecular mechanisms. Using genome wide gene expression profiling on 11 paired samples from diagnosis and relapse, we show that the expression of a substantial number of genes was altered in a highly consistent manner between these disease stages. Furthermore, the relapse associated gene expression profile was significantly enriched for leukemia stem cell (LSC) genes, indicating that recurring AML is characterized by increased stemness, and supporting the concept that it is due to the outgrowth of chemotherapy resistant LSCs.
Overall design Paired peripheral blood samples from the times of diagnosis and relapse were obtained from 11 patients with cytogenetically normal AML. cRNA was hybridized to Affymetrix human ST1.1 arrays.
Contributor(s) Wieser R, Hackl H
Citation(s) 25030037
Submission date Mar 04, 2015
Last update date Nov 08, 2016
Contact name Rotraud Wieser
Organization name Medical University of Vienna
Department Clinic of Medicine I
Street address Waehringer Guertel 18-20
City Vienna
ZIP/Postal code 1090
Country Austria
Platforms (1)
GPL11532 [HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version]
Samples (22)
GSM1624440 CN AML patient 1 Dg
GSM1624441 CN AML patient 1 R
GSM1624442 CN AML patient 2 Dg
BioProject PRJNA277190

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Supplementary file Size Download File type/resource
GSE66525_RAW.tar 96.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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