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Status 
Public on Jul 14, 2015 
Title 
A DNA Hypomethylation Signature Predicts Novel AntiTumor Activity of LSD1 Inhibitors in SCLC 
Organism 
Homo sapiens 
Experiment type 
Expression profiling by array Genome binding/occupancy profiling by high throughput sequencing Methylation profiling by array

Summary 
This SuperSeries is composed of the SubSeries listed below.



Overall design 
Refer to individual Series



Citation(s) 
26175415 
Submission date 
Feb 25, 2015 
Last update date 
May 15, 2019 
Contact name 
David Soong 
Organization name 
GlaxoSmithKline

Street address 
1250 S Collegeville Rd

City 
Collegeville 
State/province 
PA 
ZIP/Postal code 
19426 
Country 
USA 


Platforms (3) 
GPL570 
[HGU133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array 
GPL11154 
Illumina HiSeq 2000 (Homo sapiens) 
GPL13534 
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) 

Samples (136)

GSM1618912 
SHP77, 552A for 2 days, rep 2 
GSM1618913 
SHP77, DMSO for 4 days, rep 1 
GSM1618914 
SHP77, DMSO for 4 days, rep 2 
GSM1618915 
SHP77, 552A for 4 days, rep 1 
GSM1618916 
SHP77, 552A for 4 days, rep 2 
GSM1618917 
SHP77, DMSO for 7 days, rep 1 
GSM1618918 
NCIH526, DMSO for 2 days, rep 1 
GSM1618919 
NCIH526, DMSO for 2 days, rep 2 
GSM1618920 
NCIH526, 552A for 2 days, rep 1 
GSM1618921 
NCIH526, 552A for 2 days, rep 2 
GSM1618922 
NCIH526, 552A for 2 days, rep 3 
GSM1618923 
NCIH526, DMSO for 4 days, rep 1 
GSM1618924 
NCIH526, DMSO for 4 days, rep 2 
GSM1618925 
NCIH526, 552A for 4 days, rep 1 
GSM1618926 
NCIH526, 552A for 4 days, rep 2 
GSM1618927 
NCIH526, DMSO for 7 days, rep 1 
GSM1618928 
NCIH526, DMSO for 7 days, rep 2 
GSM1618929 
NCIH526, 552A for 7 days, rep 1 
GSM1618930 
NCIH526, 552A for 7 days, rep 2 
GSM1618931 
NCIH510, DMSO for 2 days, rep 1 
GSM1618932 
NCIH510, DMSO for 2 days, rep 2 
GSM1618933 
NCIH510, 552A for 2 days, rep 1 
GSM1618934 
NCIH510, 552A for 2 days, rep 2 
GSM1618935 
NCIH510, DMSO for 4 days, rep 1 
GSM1618936 
NCIH510, DMSO for 4 days, rep 2 
GSM1618937 
NCIH510, 552A for 4 days, rep 1 
GSM1618938 
NCIH510, 552A for 4 days, rep 2 
GSM1618939 
NCIH510, DMSO for 7 days, rep 1 
GSM1618940 
NCIH510, DMSO for 7 days, rep 2 
GSM1618941 
NCIH510, 552A for 7 days, rep 1 
GSM1618942 
NCIH510, 552A for 7 days, rep 2 
GSM1618943 
COLO668, DMSO for 2 days, rep 1 
GSM1618944 
COLO668, DMSO for 2 days, rep 2 
GSM1618945 
COLO668, 552A for 2 days, rep 1 
GSM1618946 
COLO668, 552A for 2 days, rep 2 
GSM1618947 
COLO668, DMSO for 4 days, rep 1 
GSM1618948 
COLO668, 552A for 4 days, rep 1 
GSM1618949 
COLO668, DMSO for 7 days, rep 1 
GSM1618950 
COLO668, 552A for 7 days, rep 1 
GSM1618951 
COLO668, 552A for 7 days, rep 2 
GSM1618952 
NCIH146, DMSO for 2 days, rep 1 
GSM1618953 
NCIH146, 552A for 2 days, rep 1 
GSM1618954 
NCIH146, 552A for 2 days, rep 2 
GSM1618955 
NCIH146, DMSO for 4 days, rep 1 
GSM1618956 
NCIH146, DMSO for 4 days, rep 2 
GSM1618957 
NCIH146, 552A for 4 days, rep 1 
GSM1618958 
NCIH146, 552A for 4 days, rep 2 
GSM1618959 
NCIH146, DMSO for 7 days, rep 1 
GSM1618960 
NCIH146, DMSO for 7 days, rep 2 
GSM1618961 
NCIH146, 552A for 7 days, rep 1 
GSM1618962 
NCIH146, 552A for 7 days, rep 2 
GSM1618963 
NCIH446, DMSO for 2 days, rep 1 
GSM1618964 
NCIH446, DMSO for 2 days, rep 2 
GSM1618965 
NCIH446, 552A for 2 days, rep 1 
GSM1618966 
NCIH446, 552A for 2 days, rep 2 
GSM1618967 
NCIH446, DMSO for 4 days, rep 1 
GSM1618968 
NCIH446, 552A for 4 days, rep 1 
GSM1618969 
NCIH446, 552A for 4 days, rep 2 
GSM1618970 
NCIH446, DMSO for 7 days, rep 1 
GSM1618971 
NCIH446, 552A for 7 days, rep 1 
GSM1618972 
SHP77, DMSO for 7 days, rep 2 
GSM1618973 
SHP77, 552A for 7 days, rep 1 
GSM1618974 
SHP77, 552A for 7 days, rep 2 
GSM1618975 
SHP77, 552A for 7 days, rep 3 
GSM1618976 
SHP77, 552A for 7 days, rep 4 
GSM1618977 
COLO668, DMSO for 7 days, rep 2 
GSM1618978 
NCIH146, DMSO for 2 days, rep 2 
GSM1618979 
NCIH446, DMSO for 4 days, rep 2 
GSM1618980 
NCIH446, DMSO for 4 days, rep 3 
GSM1618981 
NCIH446, DMSO for 7 days, rep 2 
GSM1618982 
NCIH446, 552A for 7 days, rep 2 
GSM1618983 
COLO668, DMSO for 4 days, rep 2 
GSM1618984 
COLO668, 552A for 4 days, rep 2 
GSM1618985 
H69, DMSO for 4 days, rep 1 
GSM1618986 
H69, DMSO for 4 days, rep 2 
GSM1618987 
H69, 552A for 4 days, rep 1 
GSM1618988 
H69, 552A for 4 days, rep 2 
GSM1618989 
H2171, DMSO for 4 days, rep 1 
GSM1618990 
H2171, DMSO for 4 days, rep 2 
GSM1618991 
H2171, 552A for 4 days, rep 1 
GSM1618992 
H2171, 552A for 4 days, rep 2 
GSM1618993 
H1417, DMSO for 4 days, rep 1 
GSM1618994 
H1417, DMSO for 4 days, rep 2 
GSM1618995 
H1417, 552A for 4 days, rep 1 
GSM1618996 
H1417, 552A for 4 days, rep 2 
GSM1618997 
COLO668 
GSM1618998 
DMS 153 
GSM1618999 
DMS114 
GSM1619000 
DMS53 
GSM1619001 
H1417 
GSM1619002 
H2029 
GSM1619003 
LX101x PDX 
GSM1619004 
LX102x PDX 
GSM1619005 
LX108x PDX 
GSM1619006 
LX110x PDX 
GSM1619007 
LX22x PDX 
GSM1619008 
LX33x PDX 
GSM1619009 
LX36x PDX 
GSM1619010 
LX44 PDX 
GSM1619011 
LX47x PDX 
GSM1619012 
LX48x PDX 
GSM1619013 
LX88x PDX 
GSM1619014 
NCIH1048 
GSM1619015 
NCIH1092 
GSM1619016 
NCIH187 
GSM1619017 
NCIH1930 
GSM1619018 
NCIH2081 
GSM1619019 
NCIH2171 
GSM1619020 
NCIH446 
GSM1619021 
NCIH510 
GSM1619022 
NCIH524 
GSM1619023 
NCIH526 
GSM1619024 
NCIH69 
GSM1619025 
NCIH82 
GSM1619026 
SCLC3 
GSM1619027 
SHP77 
GSM1619029 
01C patient 
GSM1619030 
02C patient 
GSM1619031 
03C patient 
GSM1619032 
04C patient 
GSM1619033 
05C patient 
GSM1619034 
06C patient 
GSM1619035 
07C patient 
GSM1619036 
08C patient 
GSM1619037 
09C patient 
GSM1619038 
10C patient 
GSM1619039 
11C patient 
GSM1619040 
1_H526DMSO_LSD1 
GSM1619041 
2_H526GSK552_LSD1 
GSM1619042 
3_H526DMSO_H3K4me2 
GSM1619043 
5_H526DMSO_H3K4me1 
GSM1619044 
7_H526DMSO_Input 
GSM1619045 
8_H526GSK552_Input 

This SuperSeries is composed of the following SubSeries: 
GSE66294 
A DNA Hypomethylation Signature Predicts Novel AntiTumor Activity of LSD1 Inhibitors in SCLC (microarray) 
GSE66295 
A DNA Hypomethylation Signature Predicts Novel AntiTumor Activity of LSD1 Inhibitors in SCLC (BeadChip) 
GSE66297 
A DNA Hypomethylation Signature Predicts Novel AntiTumor Activity of LSD1 Inhibitors in SCLC (ChIPSeq) 

Relations 
BioProject 
PRJNA276451 




