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Series GSE66210 Query DataSets for GSE66210
Status Public on Mar 31, 2015
Title Epigenome analysis of first trimester CVS samples from normal and Trisomy 13,18,21 pregnancies, and maternal whole blood samples.
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Genome wide DNA methylation profiling of normal and trisomic placentas, and maternal blood cell DNA. The aim of this study was to search for methylation differences between maternal and fetal(placenta) cell free DNA, and between normal and trisomic placentas for an optimized methylation based noninvasive prenatal diagnosis of fetal chromosomal aberations. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in DNA samples from Chorionic villus samples(CVS) and DNA samples from whole blood. Samples included 12 Maternal blood cell samples from normal pregnancies, 12 normal CVS, 12 Trisomy 21 CVS, 12 trisomy 18 CVS and 6 trisomy 13 CVS samples.
Overall design Bisulphite converted DNA from the 54 samples were hybridized to the Illumina Infinium 450k Human Methylation Beadchip.
Contributor(s) Aagaard MM, Graakjaer J, Hatt L, Bojesen A, Kolvraa S, Bach C, Sommer S, Agerholm I
Citation(s) 26230497
Submission date Feb 23, 2015
Last update date Jul 30, 2019
Contact name Anders Bojesen
Phone +4579406604
Organization name Vejle Hospital
Department Department of Clinical Genetics
Street address Kabbeltoft 25
City Vejle
ZIP/Postal code 7100
Country Denmark
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (60)
GSM1616986 maternal_whole_blood_rep1
GSM1616987 maternal_whole_blood_rep2
GSM1616988 maternal_whole_blood_rep3
BioProject PRJNA276176

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE66210_RAW.tar 663.3 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table

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