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Series GSE66173 Query DataSets for GSE66173
Status Public on Jun 22, 2015
Title Genetic disruption of COX-1 inhibits multiple oncogenic pathways
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We performed RNA sequencing in isogenic models of COX-1 proficient (OV3/SCR) and COX-1 deficient (OV3/COX1KD) OVCAR-3 ovarian cancer cells. COX-1 knockdown was associated with a coordinated anti-oncogenic phenotype, with growth, angiogenesis, migration/invasion, and epithelial-mesenchymal transition among the pathways down-regulated.
Overall design RNA sequencing was performed at Vanderbilt Technologies for Advanced Genomics (VANTAGE) using Illumina HiSeq 2500.
Contributor(s) Khabele D
Citation(s) 25972361
Submission date Feb 20, 2015
Last update date May 15, 2019
Contact name Dineo Khabele
E-mail(s) dineo.khabele@Vanderbilt.Edu
Phone 615-322-3106
Organization name Vanderbily University
Street address 1161 21st Avenue South
City Nashville
ZIP/Postal code 37232
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (6)
GSM1616200 OV3/SCR, rep 1
GSM1616201 OV3/SCR, rep 2
GSM1616202 OV3/SCR, rep 3
BioProject PRJNA276014
SRA SRP055392

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE66173_grp_ShScr_vs_ShCOX1.txt.gz 506.9 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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