|
| Status |
Public on Jun 22, 2015 |
| Title |
Genetic disruption of COX-1 inhibits multiple oncogenic pathways |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We performed RNA sequencing in isogenic models of COX-1 proficient (OV3/SCR) and COX-1 deficient (OV3/COX1KD) OVCAR-3 ovarian cancer cells. COX-1 knockdown was associated with a coordinated anti-oncogenic phenotype, with growth, angiogenesis, migration/invasion, and epithelial-mesenchymal transition among the pathways down-regulated.
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| |
|
| Overall design |
RNA sequencing was performed at Vanderbilt Technologies for Advanced Genomics (VANTAGE) using Illumina HiSeq 2500.
|
| |
|
| Contributor(s) |
Khabele D |
| Citation(s) |
25972361 |
| |
| Submission date |
Feb 20, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Dineo Khabele |
| E-mail(s) |
dineo.khabele@Vanderbilt.Edu
|
| Phone |
615-322-3106
|
| Organization name |
Vanderbily University
|
| Street address |
1161 21st Avenue South
|
| City |
Nashville |
| ZIP/Postal code |
37232 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA276014 |
| SRA |
SRP055392 |
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