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Series GSE66094 Query DataSets for GSE66094
Status Public on Dec 31, 2015
Title Gene expression analysis to characterize similarities and differences in T. canis- or T. cati-induced neurotoxocarosis
Organism Mus musculus
Experiment type Expression profiling by array
Summary Larvae of Toxocara canis and T. cati show affinities to different tissues within the paratenic host. T. canis preferably migrates to the CNS whereat T. cati prefers muscle tissue. As both species share many characteristics like antigen fractions, reasons for this behaviour as well as underlying pathomechanisms or host reactions towards the respective parasite are unknown. Therefore, it was aimed to characterize the general pathogenesis as well as the respective host's reaction on the transcriptional level to identify similarities and differences between T. canis- and T. cati-infected brains.
Overall design Transcriptional changes in cerebra as well as cerebella of T. canis- and T. cati-infected C57Bl/6J mice were analysed 42 days post infection. In each infection group, 3 animals were included and 4 animals in the uninfected control.
Contributor(s) Janecek E, Wilk E, Schughart K, Geffers R, Strube C
Citation(s) 31557153
Submission date Feb 19, 2015
Last update date Oct 21, 2019
Contact name Robert Geffers
Phone +49 531-6181-3058
Organization name HCI - Helmholtz Centre for Infection Research
Department Dep. Molecular Bacteriology
Lab Genome Analytics
Street address Inhoffenstr. 7
City Braunschweig
ZIP/Postal code 38124
Country Germany
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (20)
GSM1614204 Cerebrum_T. canis_42d_rep1
GSM1614205 Cerebrum_T. canis_42d_rep2
GSM1614206 Cerebrum_T. canis_42d_rep3
BioProject PRJNA275865

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE66094_RAW.tar 43.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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