|Public on Dec 31, 2015
|Gene expression analysis to characterize similarities and differences in T. canis- or T. cati-induced neurotoxocarosis
|Expression profiling by array
|Larvae of Toxocara canis and T. cati show affinities to different tissues within the paratenic host. T. canis preferably migrates to the CNS whereat T. cati prefers muscle tissue. As both species share many characteristics like antigen fractions, reasons for this behaviour as well as underlying pathomechanisms or host reactions towards the respective parasite are unknown. Therefore, it was aimed to characterize the general pathogenesis as well as the respective host's reaction on the transcriptional level to identify similarities and differences between T. canis- and T. cati-infected brains.
|Transcriptional changes in cerebra as well as cerebella of T. canis- and T. cati-infected C57Bl/6J mice were analysed 42 days post infection. In each infection group, 3 animals were included and 4 animals in the uninfected control.
|Janecek E, Wilk E, Schughart K, Geffers R, Strube C
|Feb 19, 2015
|Last update date
|Oct 21, 2019
|HCI - Helmholtz Centre for Infection Research
|Dep. Molecular Bacteriology
|Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)