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Series GSE65686 Query DataSets for GSE65686
Status Public on Mar 04, 2015
Title Genome-wide mRNA expression profiling for Wild Type and Itch-/- Skin Transcriptomes by RNA sequencing
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To test the hypothesis that defects in the termination of inflammatory signaling led to skin inflammation that results in the “Itchy” phenotype, we isolated RNA from the lesional skin of Itch-/- mice and from the skin of wild-type mice and performed genome-wide mRNA expression profiling by RNA sequencing. We ranked genes based on the fold change in their expression (increased or decreased) in Itch-/- skin relative to that in wild-type skin. The expression of several TNF–induced genes were increased in Itch-/- skin, including, IL-1β, IL-6, IL-11, IL-19, IL-1RL1, CCL4, CXCL3, CXCL2, CCL3, and CD14.
Overall design mRNA profiles comparison between wild type (WT) skin and Itch-/- mice lesional skin
Contributor(s) Venuprasad P
Citation(s) 25714464
Submission date Feb 05, 2015
Last update date Mar 16, 2023
Contact name Nicole Baldwin
Organization name Baylor Research Institute
Street address 3434 Live Oak St
City Dallas
ZIP/Postal code 75204
Country USA
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (4)
GSM1603202 WT Skin 1
GSM1603203 WT Skin 2
GSM1603204 Itch KO Skin 1
BioProject PRJNA274745
SRA SRP053292

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Supplementary file Size Download File type/resource
GSE65686_RAW.tar 600.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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