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| Status |
Public on Nov 20, 2007 |
| Title |
Expression data from intracranial arteries and intracranial aneurysms |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression information is useful in prioritizing candidate genes in linkage intervals. The data can also identify pathways involved in the pathophysiology of disease.
We used microarrays to identify which genes are expressed in either intracranial arteries (control) or in intracranial aneurysms (case), and can therefore contribute to the disease phenotypes.
We used microarrays to identify the pathway membership of expressed genes and the overrepresentation of pathways with expressed genes in the known linkage intervals for intracranial aneurysms.
Keywords: Characterization of expression in both diseased and non-diseased intracranial arteries.
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| Overall design |
Intracranial vessels and intracranial aneurysms were obtained from cadavers and preserved in RNAlater. RNA was isolated in pools for aneurysms and some arteries, due to limited amounts of tissue and RNA, whereas intracranial artery RNA for 5 samples was obtained from single individuals.
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| Contributor(s) |
Tromp G, Kuivaniemi H, Weinsheimer S, Lenk GM |
| Citation(s) |
17878320 |
| Submission date |
Dec 17, 2006 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Gerard Tromp |
| E-mail(s) |
gerard.tromp@sanger.med.wayne.edu
|
| Phone |
313-577-8773
|
| Fax |
313-577-5218
|
| Organization name |
Wayne State University School of Medicine
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| Department |
Center for Molecular Medicine and Genetics
|
| Street address |
3309 Scott Hall, 540 East Canfield Ave
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| City |
Detroit |
| State/province |
MI |
| ZIP/Postal code |
48201 |
| Country |
USA |
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| Platforms (2) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
| GPL2507 |
Sentrix Human-6 Expression BeadChip |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA98593 |
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