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Series GSE65362 Query DataSets for GSE65362
Status Public on May 21, 2015
Title Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
Overall design We investigated a set of 562 ependymal tumors using the Illumina 450k methylation array.
Contributor(s) Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwill F, Tatevossian R, Punchihewa C, Mack S, Ramaswamy V, Johann P, Rhyzova M, Capper D, Warnatz HJ, Reimand J, Sieber L, Wittmann A, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Avigad S, Hoffman LM, Donson AM, Gilbert M, Armstrong T, Kulozik AE, Witt O, Collins VP, von Hoff K, Pietsch T, Bader G, Yaspo ML, von Deimling A, Lichter P, Taylor MD, Gilbertson R, Ellison D, Aldape K, Korshunov A, Kool M, Pfister SM
Citation(s) 25965575
Submission date Jan 27, 2015
Last update date Sep 14, 2023
Contact name Martin Sill
Organization name DKFZ
Department Division of Pediatric Neurooncology
Street address Im Neuenheimer Feld 280
City Heidelberg
ZIP/Postal code 69120
Country Germany
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (562)
GSM1593169 Brain tumor 9305651005_R04C01
GSM1593170 Brain tumor 9305651003_R02C02
GSM1593171 Brain tumor 9305651013_R02C01
BioProject PRJNA273777

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE65362_Matrixprocessed.txt.gz 2.1 Gb (ftp)(http) TXT
GSE65362_Matrixsignal.txt.gz 4.4 Gb (ftp)(http) TXT
GSE65362_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data are available on Series record

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