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| Status |
Public on Jul 03, 2015 |
| Title |
Chronic growth factor signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature [Methylation] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
We performed genome-wide DNaseI hypersensitive site in FLT3-ITD and WT patient samples. We report corresponding gene expression, promoter methylation patterns of differential DHSs as well as differentially occupied TF binding motifs using surrounding DNAseI cut profiles. We examined association patterns of FLT3 ITD and WT AMLs and found that FLT3-ITD signaling is associated with common gene expression and chromatin signature.
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| Overall design |
Examination of DNA methylation patterns in FLT3 ITD and WT AML via microarray study.
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| Contributor(s) |
Cauchy P, James S, Ptasinska A, Zacarias-Cabeza J, Imperato MR, Assi S, Piper J, Ott S, Bonifer C, Cockerill P |
| Citation(s) |
26212328 |
| Submission date |
Jan 13, 2015 |
| Last update date |
Mar 22, 2019 |
| Contact name |
Pierre Daniel Cauchy |
| E-mail(s) |
cauchy@ie-freiburg.mpg.de
|
| Phone |
+49 (0)761 5108-730
|
| Organization name |
Max Planck Institute of Immunobiology and Epigenetics
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| Department |
Department of Cellular and Molecular Immunology
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| Lab |
Laboratory Rudolf Grosschedl
|
| Street address |
Stübeweg 51
|
| City |
Freiburg |
| State/province |
Baden-Württemberg |
| ZIP/Postal code |
79108 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE64874 |
Chronic growth factor signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature |
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| Relations |
| BioProject |
PRJNA272531 |
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