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Series GSE64864 Query DataSets for GSE64864
Status Public on Jul 03, 2015
Title Chronic growth factor signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature [DNAse-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We performed genome-wide DNaseI hypersensitive site in FLT3-ITD and WT patient samples. We report corresponding gene expression, promoter methylation patterns of differential DHSs as well as differentially occupied TF binding motifs using surrounding DNAseI cut profiles. We examined association patterns of FLT3 ITD and WT AMLs and found that FLT3-ITD signaling is associated with common gene expression and chromatin signature.
 
Overall design Examination of genome-wide DNaseI hypersensitivite sites in FLT3 ITD and WT AML.
 
Contributor(s) Cauchy P, James S, Ptasinska A, Zacarias-Cabeza J, Imperato MR, Assi S, Piper J, Ott S, Bonifer C, Cockerill P
Citation(s) 26212328
Submission date Jan 12, 2015
Last update date May 15, 2019
Contact name Pierre Daniel Cauchy
E-mail(s) cauchy@ie-freiburg.mpg.de
Phone +49 (0)761 5108-730
Organization name Max Planck Institute of Immunobiology and Epigenetics
Department Department of Cellular and Molecular Immunology
Lab Laboratory Rudolf Grosschedl
Street address St├╝beweg 51
City Freiburg
State/province Baden-W├╝rttemberg
ZIP/Postal code 79108
Country Germany
 
Platforms (3)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (18)
GSM1581819 CD14_PBSC_DNAse-Seq
GSM1581820 CD34_PBSC_DNAse-Seq
GSM1581821 FLT3_ITD1_lane1_DNAse-Seq
This SubSeries is part of SuperSeries:
GSE64874 Chronic growth factor signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature
Relations
BioProject PRJNA272427
SRA SRP052030

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE64864_H17606_sorted_from_ordered_tag_gff_bin1_bin10.wig.gz 237.9 Mb (ftp)(http) WIG
GSE64864_RAW.tar 551.0 Mb (http)(custom) TAR (of WIG)
GSE64864_SN513_R302_MERGED_J15668_sorted_from_ordered_tag_gff_bin1_bin10.wig.gz 193.5 Mb (ftp)(http) WIG
GSE64864_r63_b_190_ATCACG_L003_L004_R1_001_treat_afterfiting_all_fixed.wig.gz 97.1 Mb (ftp)(http) WIG
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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