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| Status |
Public on Jul 03, 2015 |
| Title |
Chronic growth factor signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature [DNAse-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We performed genome-wide DNaseI hypersensitive site in FLT3-ITD and WT patient samples. We report corresponding gene expression, promoter methylation patterns of differential DHSs as well as differentially occupied TF binding motifs using surrounding DNAseI cut profiles. We examined association patterns of FLT3 ITD and WT AMLs and found that FLT3-ITD signaling is associated with common gene expression and chromatin signature.
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| |
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| Overall design |
Examination of genome-wide DNaseI hypersensitivite sites in FLT3 ITD and WT AML.
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| |
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| Contributor(s) |
Cauchy P, James S, Ptasinska A, Zacarias-Cabeza J, Imperato MR, Assi S, Piper J, Ott S, Bonifer C, Cockerill P |
| Citation(s) |
26212328 |
| Submission date |
Jan 12, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Pierre Daniel Cauchy |
| E-mail(s) |
cauchy@ie-freiburg.mpg.de
|
| Phone |
+49 (0)761 5108-730
|
| Organization name |
Max Planck Institute of Immunobiology and Epigenetics
|
| Department |
Department of Cellular and Molecular Immunology
|
| Lab |
Laboratory Rudolf Grosschedl
|
| Street address |
Stübeweg 51
|
| City |
Freiburg |
| State/province |
Baden-Württemberg |
| ZIP/Postal code |
79108 |
| Country |
Germany |
| |
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| Platforms (3) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (18)
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| This SubSeries is part of SuperSeries: |
| GSE64874 |
Chronic growth factor signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature |
|
| Relations |
| BioProject |
PRJNA272427 |
| SRA |
SRP052030 |
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