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Series GSE6475 Query DataSets for GSE6475
Status Public on Dec 12, 2006
Title Acne lesion vs. normal skin. Also includes non-acne patients' normal skin samples.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. In an attempt to understand the specific genes involved in inflammatory acne, we performed gene expression profiling in acne patients. Skin biopsies were obtained from an inflammatory papule and from normal skin in six patients with acne. Biopsies were also taken from normal skin of six subjects without acne. Gene array expression profiling was conducted using Affymetrix HG-U133A 2.0 arrays comparing lesional to nonlesional skin in acne patients and comparing nonlesional skin from acne patients to skin from normal subjects. Within the acne patients, 211 genes are upregulated in lesional skin compared to nonlesional skin. A significant proportion of these genes are involved in pathways that regulate inflammation and extracellular matrix remodeling, and they include matrix metalloproteinases 1 and 3, IL-8, human beta-defensin 4, and granzyme B. These data indicate a prominent role of matrix metalloproteinases, inflammatory cytokines, and antimicrobial peptides in acne lesions. These studies are the first describing the comprehensive changes in gene expression in inflammatory acne lesions and are valuable in identifying potential therapeutic targets in inflammatory acne.
Keywords: acne lesion, normal skin
Overall design total 18 chips. 6 for acne lesion samples, 6 for normal skin samples, 6 for non-acne patient normal skin samples
Contributor(s) Thiboutot DM
Citation(s) 16528362
Submission date Dec 07, 2006
Last update date Dec 06, 2018
Contact name Wei Zhao
Phone 717 531 1262
Organization name Penn State University
Street address 600 Centerview Drive, A210
City Hershey
State/province PA
ZIP/Postal code 17033
Country USA
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (18)
GSM148725 Pt_1 Acne Lesion
GSM148748 Pt_1 Normal Skin
GSM148762 Pt_2 Acne Lesion
BioProject PRJNA98713

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6475_RAW.tar 57.2 Mb (http)(custom) TAR (of CEL)

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