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Series GSE64734 Query DataSets for GSE64734
Status Public on Jan 07, 2015
Title Gene expression profiling of prefrontal cortices of mice subjected to acute and chronic social stress
Organism Mus musculus
Experiment type Expression profiling by array
Summary In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays. The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

The study was supported by Grant N N311 604938, 2011/03/N/NZ29/05222 and partially by IP2011 030371. Statistical analysis of microarray data was supported with Grant N N519 657940.
Overall design We studied gene expression profiles of prefrontal cortices of male mice subjected to social stress of different durations: Comparisons included: acute stress (24 hours after single social stress episode) vs. acute control (unstressed), stress-8 days vs. control-8 days, stress-13 days vs. control-13 days, stress-13 days+5 days of rest vs. control-13 days+5 days of rest. For each comparison, we analyzed 3 biological replicates per group. Two of out of three biological replicates were further replicated in dye swap (final dye swap failed due to problem during microarray hybridization). Each biological replicate consisted of equal amounts of total RNA from 3 mice subjected to the same experimental condition.
Contributor(s) Stankiewicz AM, Goscik J, Swiergiel AH, Majewska A, Wieczorek M, Juszczak GR, Lisowski P
Citation(s) 25472829
Submission date Jan 07, 2015
Last update date Jan 19, 2018
Contact name Adrian Mateusz Stankiewicz
Organization name Institute of Genetics and Animal Breeding of the Polish Academy of Sciences
Department Animal Behaviour
Street address Jastrzebiec, ul. Postepu 36A
City Magdalenka
State/province Mazovia
ZIP/Postal code 05-552
Country Poland
Platforms (1)
GPL10333 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version)
Samples (20)
GSM1579024 1-1 S5 K3
GSM1579025 1-2 S5 K3
GSM1579026 1-2 S3 K5
BioProject PRJNA271746

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE64734_RAW.tar 311.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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