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Series GSE64588 Query DataSets for GSE64588
Status Public on Jul 01, 2015
Title Molecular phenotyping of a test compound (small-molecule neurotransmitter receptor antagonist) in primary human hepatocytes
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Expression profiles of 917 pathway repoter genes were determined by AmpliSeq-RNA in primary human hepatocytes treated with Diclofenac and a test compound 3 hours after treatment.
Overall design Vehicle control, diclofenac, and three doses of the test compound (small-molecule neurotransmitter receptor antagonist) were applied to three primary cell lines, with three biological replicates in each group. In some treatment groups read-outs were only available for two samples. All together 41 samples were profiled.
Contributor(s) Zhang JD, Kueng E, Boess F, Certa U, Ebeling M
Citation(s) 25903797
Submission date Dec 30, 2014
Last update date May 15, 2019
Contact name Jitao David Zhang
Phone +41616886251
Organization name F. Hoffmann-La Roche
Department Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel
Lab Pharmaceutical Sciences
Street address Grenzacherstrasse 124
City Basel
ZIP/Postal code 4070
Country Switzerland
Platforms (1)
GPL17303 Ion Torrent Proton (Homo sapiens)
Samples (41)
GSM1574744 PHH1_Control IonXpress_001
GSM1574745 PHH1_Compound_1uM IonXpress_002
GSM1574746 PHH1_Compound_3uM IonXpress_003
BioProject PRJNA271358
SRA SRP051626

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Supplementary file Size Download File type/resource
GSE64588_MPS-expression.gct.txt.gz 60.8 Kb (ftp)(http) TXT
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