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Series GSE64495 Query DataSets for GSE64495
Status Public on May 28, 2015
Title DNA methylation profiles of human blood samples from a severe developmental disorder and controls
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Human DNA methylation Beadchip v1.2 was used to obtain n=113 Illumina DNA methylation array from whole blood samples.
The main goal of the study was to measure the epigenetic age (also known as DNA methylation age) of subjects with a severe developmental disorder (known as syndrome X) and controls. To measure DNA methylation age, we used the epigenetic clock software described in Horvath S (n=2013) DNA methylation age of human tissues and cell types. Genome Biology.2013, 14:R115. DOI: 10.1186/10.1186/gb-2013-14-10-r115 PMID: 24138928.
Overall design The data set contains 5 affected female subjects who exhibit a pure form of syndrome X. Further, the study includes two syndrome X-like subjects who also have Down syndrome and Ring- X Turner syndrome, respectively. For the diseased subjects, we collected several family members (parents and possibly siblings). We also collected several control families who do not have an affected child. Apart from family data, we also analyzed 62 blood samples from healthy controls.
Contributor(s) Horvath S, Walker R
Citation(s) 25991677
Submission date Dec 23, 2014
Last update date Jul 06, 2022
Contact name Steve Horvath
Organization name University of California, Los Angeles
Department Human Genetics
Lab Horvath
Street address 695 Charles E. Young Drive South, Box 708822
City Los Angeles
State/province CA
ZIP/Postal code 90095-7088
Country USA
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (113)
GSM1572503 genomic DNA from whole blood of subject Sample1
GSM1572504 genomic DNA from whole blood of subject Sample2
GSM1572505 genomic DNA from whole blood of subject Sample3
Reanalyzed by GSE207605
BioProject PRJNA271158

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE64495_Explanation_of_characteristic_variables2.txt.gz 1.0 Kb (ftp)(http) TXT
GSE64495_RAW.tar 183.1 Mb (http)(custom) TAR
GSE64495_datSignal.csv.gz 260.0 Mb (ftp)(http) CSV
Processed data included within Sample table

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