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Series GSE63849 Query DataSets for GSE63849
Status Public on Jun 17, 2015
Title Comparison of the DNA methylation profiles of CD19+ B lymphocytes of a pair of monozygotic twins discordant for common variable immunodeficiency
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary The methylation profiles of bisulfite-modified DNA of CD19+ cells from MZ twins discordant for CVID were compared using the Infinium HumanMethylation450 BeadChips (Illumina, Inc., San Diego, CA,). This platform allows the interrogation of >485,000 methylation sites per sample at single-nucleotide resolution, and comprises an average of 17 CpG sites per gene in the 99% of RefSeq genes. 96% of CpG islands are covered, with additional coverage in CpG island shores and the regions flanking them. The samples were hybridized in the array following the manufacturer’s instructions.
Overall design Total DNA isolated by standard procedures from CD19+ cells (total B lymphocytes) corresponding to two monozygotic twins discordant for common variable immunodeficiency.
Contributor(s) Rodríguez-Cortez VC, del Pino-Molina L, Ciudad L, Gómez-Cabrero D, Company C, Tegnér J, Rodríguez-Gallego C, López-Granados E, Ballestar E
Citation(s) 26081581
Submission date Dec 04, 2014
Last update date Mar 22, 2019
Contact name Esteban Ballestar
Organization name Josep Carreras Research Institute (IJC)
Lab Epigenetics and Immune Disease
Street address Ctra de Can Ruti, Camí de les Escoles s/n
City Badalona, Barcelona
State/province N/A = Not Applicable
ZIP/Postal code 08916
Country Spain
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (6)
GSM1558467 CD19+ cells CVID twin (replicate 1)
GSM1558468 CD19+ cells CVID twin (replicate 2)
GSM1558469 CD19+ cells CVID twin (replicate 3)
BioProject PRJNA269256

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63849_RAW.tar 183.1 Mb (http)(custom) TAR
GSE63849_non_normalized.txt.gz 16.4 Mb (ftp)(http) TXT
Processed data included within Sample table

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