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Series GSE63807 Query DataSets for GSE63807
Status Public on Nov 30, 2015
Title Transcriptome of Stabilin-1 siRNA transfected human monocytes
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Stabilin-1/CLEVER-1 is a multidomain protein present in lymphatic and vascular endothelial cells and in M2 immunosuppressive macrophages. Stabilin-1 functions in scavenging, endocytosis and leukocyte adhesion to and transmigration through the endothelial cells. We have analyzed the putative functions of Stabilin-1 in blood monocytes and found that in healthy individuals 60-80% of both CD14+CD16- and CD14+C16+ monocytes, but not CD14dimCD16+ monocytes, expressed Stabilin-1 on the surface. Microarray and RNAseq analysis was performed to get more insight into the effect of Stabilin-1 expression on human monocytes transcriptome.
Overall design The transcriptome of human monocytes transfected with Stabilin-1 siRNA was compared to that of control siRNA transfected monocytes
Contributor(s) Palani S, Elima K, Ekholm E, Jalkanen S, Salmi M
Citation(s) 26608916
Submission date Dec 03, 2014
Last update date May 15, 2019
Contact name Kati Elima
Organization name University of Turku
Department MediCity
Street address Tykistökatu 6
City Turku
ZIP/Postal code 20520
Country Finland
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (6)
GSM1557746 neg.co_d1_1
GSM1557747 Stab1siRNA_d1_1
GSM1557748 neg.co_d1_2
BioProject PRJNA269138
SRA SRP050490

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Supplementary file Size Download File type/resource
GSE63807_NormalizedData_withAnnotationsKE.txt.gz 1.5 Mb (ftp)(http) TXT
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