GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE63755 Query DataSets for GSE63755
Status Public on Dec 15, 2014
Title Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signaling and type I-IFN signaling.
Overall design Comparison of transcriptional profiles of native RNASEH2-deficient patient fibroblasts with wild type cells.
Contributor(s) Günther C, Kind B, Reijns M, Berndt N, Martinez-Bueno M, Wolf C, Tüngler V, Chara O, Lee YA, Hübner N, Bicknell L, Blum S, Krug C, Schmidt F, Kretschmer S, Koss S, Astell K, Ramantani G, Bauernfeind A, Morris D, Graham DC, Bubeck D, Leitch A, Ralston S, Blackburn E, Gahr M, Witte T, Vyse T, Melchers I, Mangold E, Nöthen M, Aringer M, Kuhn A, Lüthke K, Unger L, Bley A, Lorenzi A, Isaacs J, Alexopoulou D, Conrad K, Dahl A, Roers A, Alarcon-Riquelme M, Jackson A, Lee-Kirsch MA
Citation(s) 25500883
Submission date Dec 01, 2014
Last update date May 15, 2019
Contact name Min Ae Lee-Kirsch
Organization name TU Dresden
Department Universitätsklinikum Carl Gustav Carus
Lab Molekulare Pädiatrie
Street address Fetscherstraße 74
City Dresden
ZIP/Postal code 01307
Country Germany
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (7)
GSM1556699 WT1
GSM1556700 WT2
GSM1556701 WT3
BioProject PRJNA268979
SRA SRP050397

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63755_RPKM_RNASEH2_JCI_p156.txt.gz 57 b (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap