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Series GSE63646 Query DataSets for GSE63646
Status Public on Jan 01, 2015
Title Expression and Prognostic impact of LncRNAs in Acute Myeloid Leukemia
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis and cell-cycle. To determine whether lncRNAs are associated with clinical features and recurrent mutations in older patients (aged ≥60 years) with cytogenetically normal (CN) acute myeloid leukemia (AML), we evaluated lncRNA expression in 148 untreated older CN-AML cases using a custom microarray platform.
Overall design In this study, we analyzed a large set of older CN-AML patients using custom lncRNA microarrays to investigate whether lncRNA expression is associated with clinical features, molecular abnormalities and outcome and to build a prognostic lncRNA signature that was subsequently validated using RNA sequencing.

This submission represents RNA-Seq component of study.
Contributor(s) Garzon R, Volinia S, Papaioannou D, Nicolet D, Kohlschmidt J, Yan P, Mrózek K, Bucci D, Carroll AJ, Baer MR, Wetzler M, Carter TH, Powell BL, Kolitz JE, Moore JO, Eisfeld A, Blachly JS, Blum W, Caligiuri MA, Stone RM, Marcucci G, Croce CM, Byrd JC, Bloomfield CD
Citation(s) 25512507
Submission date Nov 25, 2014
Last update date May 15, 2019
Contact name Ramiro Garzon
Organization name The Ohio State University
Department Hematology
Street address Starling Loving Hall
City Columbus
ZIP/Postal code 43210
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (71)
GSM1554577 AML Sample 1
GSM1554578 AML Sample 2
GSM1554579 AML Sample 3
BioProject PRJNA268523
SRA SRP050272

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63646_RNAseqwithArraystarSymbols.NormalizedMatrix.xls.gz 2.2 Mb (ftp)(http) XLS
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Processed data are available on Series record
Raw data are available in SRA

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