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Series GSE63645 Query DataSets for GSE63645
Status Public on Nov 25, 2017
Title SOX7 and ETS factors regulate an endothelial transcriptional program during vascular development (DamID)
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Vascular development involves complex changes in gene expression necessary to dictate the behaviour of differentiating endothelial cells within the emerging vascular network. However, the transcriptional programs regulating vascular development are poorly understood. Here we use a DamID approach to profile for the first time the global DNA binding pattern of SOX7, FLI1 and ERG in endothelial precursor cells. We uncover that SOX7, FLI1 and ERG bind together at endothelial specific regulatory regions to drive a transcriptional program important for vascular development.
 
Overall design DamID for SOX7, FLI1 and ERG relative to WT DAM only control
 
Contributor(s) Lilly AJ, Kouskoff V
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Submission date Nov 25, 2014
Last update date May 15, 2019
Contact name Andrew Joshua Lilly
E-mail(s) zaki.fadlullah@cruk.manchester.ac.uk
Organization name CRUK Manchester Institute
Department Stem Cell Haematopoiesis
Street address Wilmslow Road
City Manchester
ZIP/Postal code M20 4BX
Country United Kingdom
 
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (5)
GSM1554572 Dam ID control (SOX7)
GSM1554573 DamID Sox7::Dam
GSM1554574 DamID Fli1::Dam
Relations
BioProject PRJNA268521
SRA SRP050271

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63645_RAW.tar 1.3 Mb (http)(custom) TAR (of XLSX)
SRA Run SelectorHelp
Processed data provided as supplementary file
Raw data are available in SRA

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