GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE635 Query DataSets for GSE635
Status Public on Aug 06, 2004
Title Identification of novel genomic determinants of cellular drug resistance in acute lymphoblastic leukemia.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Cellular drug resistance is associated with an unfavorable prognosis in pediatric acute lymphoblastic leukemia (ALL). To identify genes conferring resistance to antileukemic agents, we analyzed the expression of >12,700 genes in sensitive and resistant ALL cells obtained at diagnosis from 174 patients. This revealed 42, 59, 54 and 22 genes (P≤0.001) that were differentially expressed in B-lineage ALL that was sensitive versus resistant to prednisolone, vincristine, asparaginase or daunorubicin, respectively, with prediction accuracies of 71-76%. Notably, 149 of the discriminating genes have not been previously associated with resistance to these anticancer agents. These included carbohydrate-metabolism and transcription-associated genes for prednisolone, cytoskeleton and extracellular matrix genes for vincristine, ribosomal protein and translation-associated genes for asparaginase, and RAS signaling and nucleosome remodeling complex genes for daunorubicin. The identification of novel genomic determinants of cellular drug resistance provides new insights for overcoming drug resistance in acute lymphoblastic leukemia.
Keywords = ALL
Keywords: other
Contributor(s) Holleman A, Cheok MH, Den Boer ML, Yang W, Kazemier KM, Janka-Schaub GE, Pieters R, Evans WE
Citation(s) 15295046
Submission date Sep 08, 2003
Last update date Aug 10, 2018
Contact name William E Evans
Phone 901-495-4995
Fax 901-495-6869
Organization name St.Jude Children's Research Hospital
Department Pharmaceutical Sciences
Lab Evans
Street address 332 N. Lauderdale St.
City Memphis
State/province TN
ZIP/Postal code 38105
Country USA
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (173)
GSM9653 nl001
GSM9654 nl002
GSM9655 nl003
BioProject PRJNA87545

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE635_RAW.tar 523.9 Mb (http)(custom) TAR (of CEL)

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap