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Series GSE63344 Query DataSets for GSE63344
Status Public on Nov 08, 2016
Title Gene expression profile of wt-, S473A- and S473D-KAP1-re-expression in KAP1-depleted MDA-MB-231 cell
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We study the gene regulation function of serine 473 phosphorylation of KAP1 (pS473-KAP1) in MDA-MB-231 cells. Wild type KAP1, S473A-KAP1 (phospho-acceptor site mutant) and S473D-KAP1 (phospho-mimetic mutant) are re-expressed in KAP1 knockdown cells. We analyze the gene expression profile in these three cells and find that many mitochondrial complex genes are up-regulated in S473D-KAP1 re-expressing cells. This study provides information about pS473-KAP1-regulated gene expression.
Overall design mRNA profile of wt-, S473A- and S473D-KAP1-expressing MDA-MB-231 cells were generated by deep sequencing
Contributor(s) Cheng C, Ann DK
Citation(s) 27364555
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 GM119388 Analysis of Fis1 in Mitophagy in Mammals CALIFORNIA INSTITUTE OF TECHNOLOGY David C Chan
Submission date Nov 17, 2014
Last update date May 15, 2019
Contact name David Kong Ann
Organization name City of Hope
Street address 1500 E. Duarte Rd.
City Duarte
State/province CA
ZIP/Postal code 91010
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (3)
GSM1546358 MB231shKAP1_wt
GSM1546359 MB231shKAP1_S473A
GSM1546360 MB231shKAP1_S473D
BioProject PRJNA267545
SRA SRP049947

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Supplementary file Size Download File type/resource
GSE63344_log2_gene_rpkm.txt.gz 258.4 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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