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Series GSE63315 Query DataSets for GSE63315
Status Public on Apr 02, 2015
Title Narrow-band UVB phototherapy reverses DNA methylation changes in psoriatic epidermis
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary To obtain a comprehensive DNA methylation signature specific for the epidermal component of psoriasis and to analyze methylation changes during therapy, we performed genome-wide DNA methylation profiling of epidermal cells from 12 patients undergoing narrow-band UVB phototherapy and 12 corresponding healthy controls. A distinct DNA methylation pattern was seen in psoriasis compared to controls. An overall hypomethylation was found in psoriasis and 3665 methylation variable positions were identified. The DNA methylation pattern was reversed at the end of phototherapy in patients with clinical response.
Overall design Bisulphite converted DNA from the 47 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip.
Contributor(s) Gu X, Nylander E, Coates PJ, Fahraeus R, Nylander K
Citation(s) 25830654
Submission date Nov 14, 2014
Last update date Mar 22, 2019
Contact name Xiaolian Gu
Organization name Umeå University
Department Medical Biosciences
Lab Pathology
Street address Building 6M, 2nd floor, Umeå University
City Umeå
State/province västerbotton
ZIP/Postal code 90187
Country Sweden
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (47)
GSM1545680 Epidermis_psoriasis_PRE-UV_1
GSM1545681 Epidermis_psoriasis_PRE-UV_2
GSM1545682 Epidermis_psoriasis_PRE-UV_3
BioProject PRJNA267260

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63315_RAW.tar 183.1 Mb (http)(custom) TAR
GSE63315_signal_intensities.txt.gz 107.8 Mb (ftp)(http) TXT
Processed data included within Sample table

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