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Series GSE6321 Query DataSets for GSE6321
Status Public on Nov 23, 2006
Title Analysis of CD38+ and CD38- sub-clones derived from the same CLL patient
Organism Homo sapiens
Experiment type Expression profiling by array
Summary CD38 expression is an important prognostic marker in CLL with high levels of CD38 associated with shorter overall survival. In this study, we used gene expression profiling and protein analysis of highly purified cell-sorted CD38+ and CD38- chronic lymphocytic leukemia cells to elucidate a molecular basis for the association between CD38 expression and inferior clinical outcome. Paired CD38+ and CD38- CLL cells derived from the same patient were shown to be monoclonal by VH gene sequencing but despite this, CD38+ CLL cells possessed a distinct gene expression profile when compared with their CD38- sub-clones.
Keywords: Sub-clonal analysis of CLL cells derived from the same leukemia sample
 
Overall design These experiments compared the gene expression profile of CD38+ and CD38- sub-clones derived from 6 individual CLL patients.
 
Citation(s) 17287849
Submission date Nov 20, 2006
Last update date Dec 06, 2018
Contact name Chris Pepper
E-mail(s) peppercj@cf.ac.uk
Phone 442920743482
Organization name Cardiff University
Department Haematology
Street address Heath Park
City Cardiff
State/province Wales
ZIP/Postal code CF14 4XN
Country United Kingdom
 
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (12)
GSM146300 CLL#1 CD38- sub-clones
GSM146307 CLL#1 CD38+ sub-clones
GSM146308 CLL#2 CD38- sub-clones
Relations
BioProject PRJNA100583

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6321_RAW.tar 21.6 Mb (http)(custom) TAR (of CEL)

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