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| Status |
Public on Jul 10, 2015 |
| Title |
Expression profiles of liver tissues from wild-type and AID transgenic mice exposed to thioacetamide hepatotoxicity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
AID is an intrinsic DNA mutator enzyme and contributes to tumorigenesis through the accumulation of genetic aberrations. To examine whether mutagenesis induced by AID during inflammation-associated hepatocarcinogenesis depends on the transcriptional levels of the target genes, we performed the gene expression profiling of liver tissues from AID transgenic mice and wild-type mice with and without thioacetamide treatment.
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| Overall design |
AID transgenic mice and wild-type mice were administered with thioacetamide in drinking water for 6 months, and the gene expression levels of their livers are compared.
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| Contributor(s) |
Matsumoto T, Marusawa H |
| Citation(s) |
25969143 |
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| Submission date |
Oct 30, 2014 |
| Last update date |
Jan 19, 2018 |
| Contact name |
Tomonori Matsumoto |
| Organization name |
Osaka University
|
| Street address |
3-1 Yamadaoka
|
| City |
Suita |
| State/province |
Osaka |
| ZIP/Postal code |
565-0871 |
| Country |
Japan |
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| Platforms (1) |
| GPL10333 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version) |
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| Samples (2) |
| GSM1535473 |
thioacetamide treatment effect on wild-type mouse liver |
| GSM1535474 |
thioacetamide treatment effect on AID transgenic mouse liver |
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| Relations |
| BioProject |
PRJNA265874 |
