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Series GSE62733 Query DataSets for GSE62733
Status Public on Sep 30, 2015
Title Accumulation of epigenetic alterations at the promoters of transcriptional regulator genes in the placentas of pregnancy cases with inadequate maternal gestational weight gain
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary The concept that fetal environment correlates with health later on has been defined as developmental origins of health and disease (DOHaD), in which epigenetic modifications are considered to serve as a memory of exposure to in utero environments. Although many animal studies have demonstrated direct associations of maternal nutritional conditions during pregnancy with epigenetic alterations in the offspring, such evidence from human studies has been very limited. To gain more insight into the effects of in utero environments on the human placental epigenome, we obtained genome-wide methylation profiles for 34 postpartum placentas from pregnancies of normal and fetal growth restriction cases with various extents of maternal gestational weight gain (GWG). Whereas we initially failed to identify specific loci whose methylation is commonly altered across all subjects in each of subgroups categorized by the extent of GWG and baby’s birth weight, the application of Smirnov-Grubbs' outlier test to the same dataset revealed the accumulation of epigenetic alterations in the placentas under the adverse in utero environments. This methodology is potentially applicable to various epigenome studies for human populations. Further annotations of the genomic and functional features of loci with altered DNA methylation demonstrated that environmentally induced hyper-methylation is significantly frequently occurred at the promoter region of transcriptional regulator genes including polycomb-targets and zinc-finger genes. Aberrant epigenetic modifications at such developmental regulator loci, if occurred in fetuses in a similar manner as observed in the placentas examined in this study, would elevate the risk of developing various diseases including metabolic and mental disorders in the later life.
Overall design We subjected placentas from 14 fetal growth restriction (FGR) births and 19 births within the normal range of birth weight to genome-wide DNA methylation analysis using Infinium HumanMethylation450 BeadChip.
Contributor(s) Kawai T, Nakabayashi K, Hata K
Citation(s) 26415774, 26981364
Submission date Oct 27, 2014
Last update date Jul 26, 2019
Contact name Kazuhiko Nakabayashi
Organization name National Research Institute for Child Health and Development
Department Department of Maternal-Fetal Biology
Street address 2-10-1 Okura
City Setagaya
State/province Tokyo
ZIP/Postal code 157-8535
Country Japan
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (33)
GSM1532553 FGR_insufficient_1_placenta
GSM1532554 FGR_insufficient_2_placenta
GSM1532555 FGR_insufficient_3_placenta
BioProject PRJNA265046

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE62733_450K_GWG_Matrix_signal_intensities_141025.txt.gz 128.2 Mb (ftp)(http) TXT
GSE62733_RAW.tar 183.1 Mb (http)(custom) TAR
Processed data included within Sample table

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