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Series GSE62640 Query DataSets for GSE62640
Status Public on Oct 24, 2014
Title Analysis of sex differences in DNA methylation in human pancreatic islets
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Epigenetic factors regulate tissue-specific expression and X-chromosome inactivation. Previous studies have identified epigenetic differences between sexes in some human tissues. However, it is unclear whether epigenetic modifications contribute to sex-specific differences in insulin secretion and metabolism. In this study, we investigated the impact of sex on the genome-wide DNA methylation pattern in human pancreatic islets from 53 males and 34 females, and related the methylome to changes in expression and insulin secretion.
Overall design 53 male and 34 female human pancreatic islet samples. Normally methylated, non-methylated and fully methylated human DNA samples were included as controls
Contributor(s) Hall E, Volkov P, Dayeh T, Esguerra JL, Salö S, Eliasson L, Rönn T, Bacos K, Ling C
Citation(s) 25517766, 27029739
Submission date Oct 23, 2014
Last update date May 29, 2020
Contact name Charlotte Ling
Organization name Lund University
Department Clinical Sciences
Lab Epigenetics and Diabetes
Street address Jan Waldenströms gata 35, CRC 91:12
City Malmö
ZIP/Postal code 20502
Country Sweden
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (87)
GSM1530611 Genomic DNA from donor 89
GSM1530612 Genomic DNA from donor 90
GSM1530613 Genomic DNA from donor 92
BioProject PRJNA264618

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE62640_RAW.tar 183.1 Mb (http)(custom) TAR
GSE62640_processed_data.txt.gz 341.3 Mb (ftp)(http) TXT
GSE62640_signal_intensities.txt.gz 201.4 Mb (ftp)(http) TXT
Processed data are available on Series record

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