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Series GSE62584 Query DataSets for GSE62584
Status Public on Oct 22, 2014
Title PBMC gene expression of early onset of the first demyelinating event of acute optic neuritis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Optic neuritis (ON) is a common manifestation of multiple sclerosis (MS); it appears as the presenting symptom in about 25% of MS patients and occurs in 30–70% of patients with MS during the course of their illness
Purpose. To evaluate the molecular pathways that operate in the early phase of acute ON by studying gene expression profiles of peripheral blood mononuclear cells (PBMCs) subpopulations including CD19+ B cells, CD14+ macrophages, CD4+ and CD8+ T cells.
Overall design High throughput gene expression analysis was performed on periferal mononuclear blood cells (PBMC) samples from 6 patients within 96 hours of the acute onset of the first demyelinating event of optic neuritis and 9 age matched healthy subjects using Affymetrix Inc. technology
Contributor(s) Feldman A, Gurevich M, Huna-Baron R, Achiron A
Citation(s) 25593026
Submission date Oct 22, 2014
Last update date Dec 06, 2018
Contact name Michael Gurevich
Organization name Sheba Medical Center
Department Multiple Sclerosis Center
Lab Neurogenomics
Street address Tel-Hashomer
City Ramat-Gan
ZIP/Postal code 52621
Country Israel
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (60)
GSM1529604 CD4 Control (3857ONC68)
GSM1529605 CD4 Control (3859ONC68)
GSM1529606 CD4 Control (4692ONTH84)
BioProject PRJNA264475

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE62584_RAW.tar 114.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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