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Series GSE61912 Query DataSets for GSE61912
Status Public on Jan 15, 2015
Title Enhancer Sequence Variants and Transcription Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B Cell Lymphoma (array)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Most B cell lymphomas arise in the germinal center (GC), where humoral immune responses evolve from potentially oncogenic cycles of mutation, proliferation, and clonal selection. Although lymphoma gene expression diverges significantly from GC-B cells, underlying mechanisms that alter the activities of corresponding regulatory elements (REs) remain elusive. Here we define the complete pathogenic circuitry of human follicular lymphoma (FL), which activates or decommissions transcriptional circuits from normal GC-B cells and commandeers enhancers from other lineages. Moreover, independent sets of transcription factors, whose expression is deregulated in FL, target commandeered versus decommissioned REs. Our approach reveals two distinct subtypes of low-grade FL, whose pathogenic circuitries resemble GC-B or activated B cells. Remarkably, FL-altered enhancers also are enriched for sequence variants, including somatic mutations, which disrupt transcription factor binding and expression of circuit-linked genes. Thus, the pathogenic regulatory circuitry of FL reveals distinct genetic and epigenetic etiologies for GC-B transformation.
Overall design Gene expression analysis was performed for follicular lymphoma, pheriphal blood and germinal center B cells using Affymetrix Human Gene 1.0 ST and 2.0 ST arrays
Contributor(s) Oltz EM, Payton JE, Koues OI
Citation(s) 25607463, 27183590
Submission date Sep 30, 2014
Last update date Jan 25, 2019
Contact name Jacqueline Payton
Organization name Washington University School of Medicine
Department Pathology and Immunology
Street address 660 S. Euclid Ave
City St. Louis
State/province MO
ZIP/Postal code 63110
Country USA
Platforms (2)
GPL10739 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [probe set (exon) version]
GPL19251 [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [probe set (exon) version]
Samples (30)
GSM1517155 FL1_mRNA
GSM1517156 FL2_mRNA
GSM1517157 FL3_mRNA
This SubSeries is part of SuperSeries:
GSE62246 Enhancer Sequence Variants and Transcription Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B Cell Lymphoma
BioProject PRJNA262666

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61912_RAW.tar 221.1 Mb (http)(custom) TAR (of CEL, CHP)
Processed data provided as supplementary file

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