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Series GSE61881 Query DataSets for GSE61881
Status Public on Dec 17, 2015
Title Divergent transcriptional activation by glucocorticoids in mouse and human macrophages is the result of gain and loss of enhancers
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Genome binding/occupancy profiling by high throughput sequencing
Summary Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid receptor (GR) was detected at candidate enhancers in the vicinity of induced genes in both species and this was strongly associated with canonical GR binding motifs. However, the sets of inducible genes, the candidate enhancers, and the GR motifs within them, were highly-divergent between the two species.

This SuperSeries is composed of the SubSeries listed below.
Overall design Refer to individual Series
Citation(s) 26663721, 29241532
Submission date Sep 29, 2014
Last update date Jul 15, 2019
Contact name Alasdair W Jubb
Organization name University of Edinburgh
Department Roslin Institute
Lab Hume lab / Bickmore lab (MRC HGU)
Street address The Roslin Institute
City Easter Bush
State/province Midlothian
ZIP/Postal code EH25 9RG
Country United Kingdom
Platforms (4)
GPL11180 [HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate
GPL13158 [HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (52)
GSM1516124 mm_rep1_dex_IP
GSM1516125 mm_rep1_cont_IP
GSM1516126 mm_rep1_dex_Input
This SuperSeries is composed of the following SubSeries:
GSE61877 Genome wide binding of glucocorticoid receptor in dexamethasone treated mouse bone marrow derived macrophages
GSE61878 Genome wide binding of glucocorticoid receptor in dexamethasone treated human monocyte derived macrophages
GSE61879 Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages
BioProject PRJNA262584

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61881_RAW.tar 85.3 Mb (http)(custom) TAR (of CEL)
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