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Series GSE61879 Query DataSets for GSE61879
Status Public on Dec 17, 2015
Title Expression data from a 24h time series of dexamethasone treatment for mouse bone marrow derived macrophages
Organism Mus musculus
Experiment type Expression profiling by array
Summary Macrophages are amongst the major targets of glucocorticoids (GC) as therapeutic anti-inflammatory agents. Here we show that GC treatment of mouse and human macrophages initiates a cascade of induced gene expression including many anti-inflammatory genes. Inducible binding of the glucocorticoid receptor (GR) was detected at candidate enhancers in the vicinity of induced genes in both species and this was strongly associated with canonical GR binding motifs. However, the sets of inducible genes, the candidate enhancers, and the GR motifs within them, were highly-divergent between the two species.
Overall design 3 biological replicates of a 6 point time series for the transcriptional response to dexamethasone 100nM
Contributor(s) Jubb AW, Bickmore WA, Hume DA, Young RS
Citation(s) 26663721, 29241532
Submission date Sep 29, 2014
Last update date Jul 15, 2019
Contact name Alasdair W Jubb
Organization name University of Edinburgh
Department Roslin Institute
Lab Hume lab / Bickmore lab (MRC HGU)
Street address The Roslin Institute
City Easter Bush
State/province Midlothian
ZIP/Postal code EH25 9RG
Country United Kingdom
Platforms (1)
GPL11180 [HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate
Samples (18)
GSM1516134 BMDM-baseline-rep1
GSM1516135 BMDM-1h-dex100nM-rep1
GSM1516136 BMDM-2h-dex100nM-rep1
This SubSeries is part of SuperSeries:
GSE61881 Divergent transcriptional activation by glucocorticoids in mouse and human macrophages is the result of gain and loss of enhancers
BioProject PRJNA262585

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61879_RAW.tar 37.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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