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Series GSE61637 Query DataSets for GSE61637
Status Public on May 19, 2015
Title Regulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis [fetal liver]
Organism Mus musculus
Experiment type Expression profiling by array
Summary Over-expressed MYC binds to virtually all active promoters within a cell, although with different binding affinities, and modulates gene expression, both positively and negatively. Here, we show that during lymphomagenesis in Eµ-myc transgenic mice, MYC directly up-regulates the transcription of the core snRNP assembly genes, including PRMT5, an arginine methyltransferase, that methylates Sm proteins as an early step in lymphomagenesis. This coordinated regulatory effect is direct and is critical for snRNP biogenesis, the maintenance of effective mRNA splicing and cellular viability in cycling cells, in either fibroblasts or B-cells.
 
Overall design Total RNA obtained from isolated fetal livers subjected to 24 hours of OHT or EtOH (control).
 
Contributor(s) Koh C, Low DH
Citation(s) 25970242
Submission date Sep 22, 2014
Last update date Jun 14, 2018
Contact name Diana HP Low
E-mail(s) dlow@imcb.a-star.edu.sg
Organization name Institute of Molecular and Cell Biology
Lab Chromatin, Epigenetics & Differentiation
Street address #03-06, 61 Biopolis Drive, Proteos
City Singapore
ZIP/Postal code 138673
Country Singapore
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (8)
GSM1509745 OHT-1
GSM1509746 ctrl-1
GSM1509747 OHT-2
This SubSeries is part of SuperSeries:
GSE61638 Regulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis
Relations
BioProject PRJNA261728

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61637_Non-normalized_data.txt.gz 896.6 Kb (ftp)(http) TXT
GSE61637_RAW.tar 12.5 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table

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