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Series GSE61431 Query DataSets for GSE61431
Status Public on Sep 18, 2014
Title Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describe a systematic study of schizophrenia-associated methylomic variation in the adult brain and its relationship to changes in DNA methylation across human fetal brain development.
Results: We profile methylomic variation in matched prefrontal cortex and cerebellum brain tissue from schizophrenia patients and controls, identifying disease-associated differential DNA methylation at multiple loci, particularly in the prefrontal cortex, and confirming these differences in an independent set of adult brain samples. Our data reveal discrete modules of co-methylated loci associated with schizophrenia that are enriched for genes involved in neurodevelopmental processes and include loci implicated by genetic studies of the disorder. Methylomic data from human fetal cortex samples, spanning 23 to 184 days post-conception, indicates that disease-associated differentially methylated positions are significantly enriched for loci at which DNA methylation is dynamically altered during human fetal brain development.
Conclusions: Our data support the hypothesis that schizophrenia has an important early neurodevelopmental component, and suggest that epigenetic mechanisms may mediate these effects.
Overall design Prefrontal cortex (PFC) and cerebellum samples were obtained from 46 brains archived in the London Brain Bank for Neurodegenerative Disorders (LBBND). Of these 22 were schizophrenia cases, ands of the cases 12 were male.
Contributor(s) Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk L, Bray N, Mill J
Citation(s) 25347937
Submission date Sep 15, 2014
Last update date Mar 22, 2019
Contact name Leonard C Schalkwyk
Organization name King's College London
Department IOP-SGDP
Street address De Crespigny Park
City London
ZIP/Postal code SE5 8AF
Country United Kingdom
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (87)
GSM1507715 cerebellum subject 12
GSM1507716 cerebellum subject 49
GSM1507717 cerebellum subject 11
BioProject PRJNA261424

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61431_RAW.tar 183.1 Mb (http)(custom) TAR
GSE61431_SampleBarcode_Re-analyzedGSMs_NewGSMs.txt.gz 703 b (ftp)(http) TXT
GSE61431_dasen.csv.gz 302.2 Mb (ftp)(http) CSV
GSE61431_signal_intensities.csv.gz 197.7 Mb (ftp)(http) CSV
Processed data are available on Series record

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