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Series GSE61380 Query DataSets for GSE61380
Status Public on Sep 13, 2014
Title Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describe a systematic study of schizophrenia-associated methylomic variation in the adult brain and its relationship to changes in DNA methylation across human fetal brain development. Results: We profile methylomic variation in matched prefrontal cortex and cerebellum brain tissue from schizophrenia patients and controls, identifying disease-associated differential DNA methylation at multiple loci, particularly in the prefrontal cortex, and confirming these differences in an independent set of adult brain samples. Our data reveal discrete modules of co-methylated loci associated with schizophrenia that are enriched for genes involved in neurodevelopmental processes and include loci implicated by genetic studies of the disorder. Methylomic data from human fetal cortex samples, spanning 23 to 184 days post-conception, indicates that disease-associated differentially methylated positions are significantly enriched for loci at which DNA methylation is dynamically altered during human fetal brain development. Conclusions: Our data support the hypothesis that schizophrenia has an important early neurodevelopmental component, and suggest that epigenetic mechanisms may mediate these effects.
Overall design 33 post-mortem brain (prefrontal cortex) samples (18 schizophrenia cases and 15 controls) were obtained from Douglas Bell-Canada Brain Bank (DBCBB), Montreal, Canada. Bisulfite converted DNA from these samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip v1.0.
Contributor(s) Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk L, Bray N, Mill J
Citation(s) 25347937
Submission date Sep 12, 2014
Last update date Mar 22, 2019
Contact name Jonathan Mill
Organization name University of Exeter
Department Medical School, RILD Building
Lab Epigenetics
Street address RD&E NHS Foundation, Trust Campus, Barrack Rd
City Exeter
ZIP/Postal code EX2 5DW
Country United Kingdom
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (33)
GSM1503499 frontal cortex_subject_1
GSM1503500 frontal cortex_subject_2
GSM1503501 frontal cortex_subject_3
BioProject PRJNA260910

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61380_RAW.tar 183.1 Mb (http)(custom) TAR
GSE61380_normalized_data.txt.gz 121.3 Mb (ftp)(http) TXT
GSE61380_preprocessed_Montreal_data.txt.gz 79.3 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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