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Series GSE61228 Query DataSets for GSE61228
Status Public on Sep 09, 2014
Title Effects of Long-term Serial Passaging on the Characteristics and Properties of Cell Lines Derived From Uveal Melanoma Primary Tumors.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Development of liver metastasis remains the most common cause of mortality in uveal melanoma (UM). Although advances in genomics allowed the direct evaluation of clinical samples of this eye cancer, there is still a need for reliable preclinical models to progress from correlative studies to mechanistic investigations. A few UM cell lines have been characterized, but so far the translation of basic knowledge to the clinic for the treatment of metastatic disease has been incremental at best. The aim of this study was to determine whether the properties of UM cell lines at various passages were similar to their corresponding primary tumors.
Overall design Two primary uveal melanoma tumors and their derivative cell lines at three different passages are analyzed by gene profiling
Web link
Contributor(s) Mouriaux F, Zaniolo K, Bergeron MA, Weidmann C, De La Fouchardière A, Fournier F, Droit A, Marcos MW, Landreville S, Guérin SL
Citation(s) 27723895
Submission date Sep 08, 2014
Last update date Nov 27, 2018
Contact name Karine Zaniolo
Organization name Centre de recherche du CHU de Québec
Department CUO-Recherche
Lab Sylvain Guérin
Street address 1050 Chemin Sainte-Foy
City Québec
State/province Québec
ZIP/Postal code G1S 4L8
Country Canada
Platforms (1)
GPL13607 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)
Samples (8)
GSM1499915 Primary_uveal_melanoma_tumor_142_rep1
GSM1499916 Uveal_melanoma_derivative_cell_line_T142_passage4_rep1
GSM1499917 Uveal_melanoma_derivative_cell_line_T142_passage20_rep1
BioProject PRJNA260544

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61228_RAW.tar 102.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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