GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE60787 Query DataSets for GSE60787
Status Public on Aug 01, 2015
Title Genome-wide DNA methylation analysis of seminoma-like TCam-2 cells during transition into an embryonal carcinoma-like state
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Illumina 450k DNA methylation microarray analysis of seminoma-like TCam-2 cells xenografted in nude mice. 2120EP embryonal carcinoma cells served as control. TCam-2 cells acquire pluripotency and become epigenetically reprogrammed to an embryonal carcinoma-like state during in vivo growth. This analysis is part of the article 'BMP inhibition in seminomas initiates acquisition of pluripotency via NODAL signaling resulting in reprogramming to an embryonal carcinoma' by Nettersheim et al., 2015. PLoS Genetics
Overall design Genomic DNA was isolated from tumors of TCam-2 and 2102EP cells xenografted for 1, 2, 4 and 6 weeks as well as 4 and 8 weeks, respectively. In vivo samples of TCam-2 cells were analyzed in biological duplicates. In vitro cultivated TCam-2 / 2102EP cells as well as 2102EP xenografted for 4 and 8 weeks were analyzed once.
Contributor(s) Nettersheim D, Schorle H
Citation(s) 26226633
Submission date Aug 26, 2014
Last update date Mar 22, 2019
Contact name Daniel Nettersheim
Organization name University Hospital Düsseldorf
Department Urology
Lab Urological Research Lab, Translational Urooncology
Street address Universitätsstr. 1
City Düsseldorf
State/province NRW
ZIP/Postal code 40225
Country Germany
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (12)
GSM1488674 TCam-2 in vitro
GSM1488675 TCam-2-1w-1
GSM1488676 TCam-2-1w-2
BioProject PRJNA259542

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE60787_RAW.tar 183.1 Mb (http)(custom) TAR
GSE60787_non-normalized-signals.txt.gz 29.6 Mb (ftp)(http) TXT
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap