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Series GSE60769 Query DataSets for GSE60769
Status Public on Mar 01, 2015
Title Normal mouse skin lacking Hras
Organism Mus musculus
Experiment type Expression profiling by array
Summary Oncogenic activating mutations in Ras genes are among the most common drivers of human disease. Treating mouse skin with the chemical carcinogen DMBA induces a characteristic mutation in Hras at codon 61. To understand how skin responds to a constitutive lack of Hras, we generated a cohort of Hras knockout mice.
Overall design A backcross was generated using male Mus spretus and female FVB/N Hras-/- mice; female F1 hybrids were mated with male FVB/N Hras -/- or Hras -/+ mice to generate a backcross population. This series contains mice that were Hras -/-. Mice were aged to 8 weeks and a tail skin sample was snap frozen.
Contributor(s) Quigley DA, Balmain A
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Submission date Aug 26, 2014
Last update date Apr 18, 2017
Contact name David Quigley
Organization name UCSF
Department Helen Diller Comprehensive Cancer Center
Lab Ashworth Lab
Street address 1450 Third St. Room 207
City San Francisco
State/province CA
ZIP/Postal code 94158
Country USA
Platforms (1)
GPL11533 [MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]
Samples (105)
GSM1273209 tail-1351
GSM1273210 tail-1355
GSM1273212 tail-1357
BioProject PRJNA259516

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE60769_RAW.tar 409.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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