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Status |
Public on Oct 09, 2007 |
Title |
Molecular targets of proteasome inhibitor, bortezomib, on ATL cells |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Adult T-cell leukemia (ATL) is a fatal neoplasia derived from HTLV-1 infected T lymphocytes exhibiting constitutive activation of NF-kB. To elucidate the complex molecular mechanism of anti-tumor effect of the proteasome inhibitor, bortezomib in ATL cells, we attempted to perform gene expression profiling. Keywords: dose response
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Overall design |
Four ATL cell lines were cultured with or without bortezomib, then analysed.
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Contributor(s) |
Ohyashiki JH |
Citation(s) |
17895889 |
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Junko H Ohyashiki, Ryoko Hamamura, Chiaki Kobayashi, Yu Zhang, Kazuma Ohyashiki. 2008. A network biology approach evaluating the anticancer effects of bortezomib identifies SPARC as a therapeutic target in adult T-cell leukemia cells. October 2008 Volume 2008:1 Pages 85 - 98. DOI: http://dx.doi.org/10.2147/AABC.S4133
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Submission date |
Oct 14, 2006 |
Last update date |
Mar 25, 2019 |
Contact name |
Junko H Ohyashiki |
E-mail(s) |
junko@hh.iij4u.or.jp
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Phone |
+81-3-3342-6111(ext.5999)
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Fax |
+81-3-5381-6651
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Organization name |
Tokyo Medical University
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Department |
Intractable Immune System Diseases Research Center
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Street address |
6-7-1, Nishishinjuku, Shinjuku-ku
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City |
Tokyo |
ZIP/Postal code |
160-0023 |
Country |
Japan |
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Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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Samples (18)
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Relations |
BioProject |
PRJNA97763 |