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Series GSE60274 Query DataSets for GSE60274
Status Public on Jan 06, 2015
Title Genome-wide DNA methylation profiling of 68 GBM (primary & recurrent), 4 glioma spheres and 5 non-tumor brain samples
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary DNA methylation analysis of 68 glioblastoma specimen of patients treated within clinical trials, 5 samples of normal brain tissue (non-tumor brain) and 4 tumor-derived glioma sphere lines. The data was used to identify changes in DNA methylation which contribute to the aberrant of expression of HOX transcription factors. Our group had previously demonstrated that expression of HOX genes was associated with increased resistance to chemo-radiotherapy and worse outcome in GBM patients Keywords: Disease state comparison
Overall design Bisulphite converted genomic DNA from the 77 samples were hybridised to the Illumina Infinium 450 Human Methylation Beadchip
Contributor(s) Kurscheid S, Bady P, Hamou M, Diserens A, Stupp R, Delorenzi M, Hegi ME
Citation(s) 26482909, 25622821, 29299163, 37491696
Submission date Aug 08, 2014
Last update date Sep 15, 2023
Contact name Sebastian Kurscheid
Organization name University Hospital Lausanne (CHUV)
Department Neurosurgery
Lab Prof. Monika Hegi
Street address Rue du Bugnon 46
City Lausanne
State/province VD
ZIP/Postal code 1011
Country Switzerland
Platforms (1)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
Samples (77)
GSM1468969 genomic DNA from Surgical resection GBM-1758
GSM1468970 genomic DNA from Surgical resection GBM-1755
GSM1468971 genomic DNA from Surgical resection GBM-1496
BioProject PRJNA257898

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE60274_RAW.tar 829.9 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table

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